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目的:探讨白细胞介素-6(IL-6)和白细胞介素-8(IL-8)在慢性牙周炎中的作用,以及C-反应蛋白在慢性牙周炎龈沟液中浓度的变化。方法:采用酶联免疫吸附法测定50例慢性牙周炎患者和30例健康者龈沟液中IL-6、IL-8以及C-反应蛋白(C-reactionprotein,CRP)的含量。结果:慢性牙周炎患者龈沟液IL-6、IL-8和CRP含量分别为(451.5±11.6)g/L、(955±201.5)g/L和(33.8±8.7)g/L明显高于健康对照组(P<0.05)。结论:IL-6和IL-8与慢性牙周炎的病理变化有关,CRP作为一种炎症标志物,能有效监控慢性牙周炎的炎症情况。
Objective: To investigate the role of interleukin-6 (IL-6) and interleukin-8 (IL-8) in chronic periodontitis and the concentration of C-reactive protein in gingival crevicular fluid of patients with chronic periodontitis. Methods: The levels of IL-6, IL-8 and C-reactive protein (C-reactive protein) in 50 patients with chronic periodontitis and 30 healthy controls were measured by enzyme-linked immunosorbent assay. Results: The levels of IL-6, IL-8 and CRP in gingival crevicular fluid of patients with chronic periodontitis were (451.5 ± 11.6) g / L, (955 ± 201.5) g / L and (33.8 ± 8.7) g / L, respectively In the healthy control group (P <0.05). Conclusion: IL-6 and IL-8 are associated with the pathological changes of chronic periodontitis. CRP, as an inflammatory marker, can effectively monitor the inflammation of chronic periodontitis.