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目的:评价喉咽清口服液与阿齐霉素联用对80株金黄色葡萄球菌的体外联合抗菌效应。方法:采用棋盘法设计,微量肉汤稀释法测定不同浓度组合的抗菌药物对40株甲氧西林敏感的金黄色葡萄球菌(MSSA)和40株甲氧西林耐药的金黄色葡萄球菌(MRSA)的最低抑菌浓度,并计算FIC指数判定联合效应。结果:喉咽清口服液与阿齐霉素联合用药后,其对金黄色葡萄球菌的MIC50显著降低,FIC指数分布:40株MSSA的FIC指数分布:FIC≤0.5占36.4%;0.52为0。40株MRSA的FIC指数分布:FIC≤0.5占81.8%;0.52为0。结论:体外喉咽清口服液与阿齐霉素联用对80株金黄色葡萄球菌主要为协同和相加作用。
OBJECTIVE: To evaluate the in vitro combined antibacterial effect of HuanYaQing oral liquid and azithromycin against 80 Staphylococcus aureus. Methods: By the checkerboard design, 40 strains of methicillin-sensitive Staphylococcus aureus (MSSA) and 40 methicillin-resistant Staphylococcus aureus (MRSA) were determined by micro broth dilution method with different concentrations of antimicrobial agents. The minimum inhibitory concentration, and calculate the FIC index to determine the joint effect. Results: The MIC50 of Staphylococcus aureus was significantly lower after the combination of Huanyanqing oral liquid and azithromycin. FIC index distribution: FIC index distribution of 40 MSSA: 36.4% with FIC≤0.5; 0.5 2 was 0.40 MRSA FIC index distribution: FIC≤0.5 accounted for 81.8%; 0.5 2 is zero. CONCLUSION: The in vitro combination of Huanyu Qing oral liquid with azithromycin has the synergistic and additive effects on 80 Staphylococcus aureus.