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复方增效磺胺(co-trimoxazole)的广泛应用已导致卡氏肺孢子虫(P.c.)耐药增多。P.c.耐药性的检测颇为复杂,许多学者转向研究药物针对的酶的编码基因。二氢叶酸合成酶(DHPS)为P.c.叶酸合成所必需,可被SMZ抑制。人源P.c.DHPS基因变异可引
The widespread use of co-trimoxazole has led to increased resistance of P.c. P.c. The detection of drug resistance is quite complex and many scholars have turned to studying the gene encoding the enzyme for the drug. Dihydrofolate synthase (DHPS) is required for P.c. folic acid synthesis and can be inhibited by SMZ. Human P.c. DHPS gene variants can be cited