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目的研究2型糖尿病(T2DM)患者血尿酸水平与糖尿病视网膜病变(DR)之间的相关性。方法552例T2DM患者根据血尿酸水平分为高尿酸血症(HUA)组与正常血尿酸(NUA)组,比较两组患者的眼底病变情况。结果 T2DM伴HUA组患者的甘油三脂(TG)、总胆固醇(TC)、血清肌酐(Cr)、体重指数(BMI)、收缩压(SBP)、糖化血红蛋白(Hb A1c)及DR的发生率明显高于糖尿病NUA组患者(P<0.05),高密度脂蛋白胆固醇(HDL-C)显著低于糖尿病NUA组(P<0.05);空腹血糖(FPG)及低密度脂蛋白胆固醇(LDL-C)水平与糖尿病NUA组比较差异无统计学意义(P>0.05)。结论糖尿病患者合并HUA与糖尿病DR的发病率有明显相关性,可通过调控体重、血糖、血脂、血压、血尿酸水平预防糖尿病DR的发生与发展。
Objective To investigate the correlation between serum uric acid level and diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM). Methods 552 T2DM patients were divided into hyperuricemia (HUA) group and normal uric acid (NUA) group according to the level of serum uric acid. The fundus lesions of the two groups were compared. Results The incidence of triglyceride (TG), total cholesterol (TC), serum creatinine (Cr), body mass index (BMI), systolic blood pressure (SBP), HbA1c and DR were significantly higher in patients with T2DM and HUA (P <0.05), HDL-C was significantly lower in diabetic NUA group than in NUA diabetic group (P <0.05); fasting blood glucose (FPG) and low density lipoprotein cholesterol (LDL- There was no significant difference between the level and diabetic NUA group (P> 0.05). Conclusions There is a significant correlation between the prevalence of diabetes mellitus (HUA) and diabetes mellitus (DR). The prevention and treatment of diabetes mellitus (DR) can be prevented through the regulation of body weight, blood glucose, blood lipid, blood pressure and blood uric acid.