论文部分内容阅读
目的了解慢性乙型肝炎（慢乙肝）患者细胞免疫功能状态。方法应用流式细胞术对70例慢乙肝患者进行T细胞亚群和自然杀伤细胞活性的检测。结果慢乙肝患者CD3+细胞、CD4+细胞和自然杀伤细胞（NK）活性较对照组显著减低，CD8+细胞活性增高，CD4／CK8之值减小，并与疾病程度相关。HBeAg阳性与HBeAg阴性的患者比较，各项指标值变化有显著差异。结论慢乙肝患者存在细胞免疫功能紊乱，免疫指标的监测对于判断预后、合理选择治疗方法可能有指导意义。
Objective To understand the cellular immune function in patients with chronic hepatitis B (chronic hepatitis B). Methods T cell subsets and natural killer cell activity were detected in 70 patients with chronic hepatitis B by flow cytometry. Results The activity of CD3 + cells, CD4 + cells and natural killer cells (NK) in chronic hepatitis B patients were significantly lower than those in control group. The activity of CD8 + cells was increased and the value of CD4 / CK8 was decreased. HBeAg-positive and HBeAg-negative patients, the index values were significantly different. Conclusion There are cellular immune dysfunction in patients with chronic hepatitis B, and the monitoring of immune indexes may be instructive in judging the prognosis and judicious treatment.