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[目的]探讨和总结纵隔原发内胚窦瘤的临床特点和诊治方法。[方法]回顾性总结分析中国医学科学院肿瘤医院胸外科2000～2010年间收治的7例纵隔原发内胚窦瘤的临床诊治情况。[结果]本病好发于青年男性,平均发病年龄22.5岁。首发症状常为胸痛、咳嗽、胸闷。发病迅速,自出现症状至就诊平均18d。CT可见前纵隔密度不均肿物,平均直径11cm。肿物常侵及周边大血管及肺组织,手术根治率42.9%。术后平均生存时间6.7个月。术前辅助化疗组平均生存时间7.8个月,根治性手术组平均生存时间8.4个月,与对照组相比具有较明显优势。[结论]原发性纵隔内胚窦瘤恶性程度高、发病迅速、预后较差,术前辅助化疗及根治性完整切除肿瘤可延长患者生存时间。
[Objective] To investigate and summarize the clinical features and diagnosis and treatment of mediastinal primary endodermal sinus tumor. [Methods] The clinical diagnosis and treatment of 7 cases of mediastinum primary endodermal sinus tumor admitted to Department of Thoracic Surgery, Cancer Hospital of Chinese Academy of Medical Sciences from 2000 to 2010 were retrospectively analyzed. [Results] The disease occurs in young men, with an average age of onset of 22.5 years. The first symptom often chest pain, cough, chest tightness. Rapid onset, since the onset of symptoms to an average of 18d. CT showed uneven density of the anterior mediastinum, with an average diameter of 11cm. Often invading the tumor and surrounding large blood vessels and lung tissue, the radical cure rate of 42.9%. The mean postoperative survival time was 6.7 months. Preoperative adjuvant chemotherapy group average survival time of 7.8 months, the average survival time of radical surgery group was 8.4 months, compared with the control group has obvious advantages. [Conclusion] The primary mediastinal endodermal sinus tumor has a high degree of malignancy, rapid onset and poor prognosis. Preoperative adjuvant chemotherapy and radical radical resection of the tumor can prolong the survival time of patients.