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运用细胞培养和形态分析方法在体外观察了人胚成骨细胞分泌的基质的类型和分泌后的几种状态，并探讨了与此相关的问题，研究表明：在成骨细胞内不同部位形成球形和均质无定形基质，提示成骨细胞对基质的合成是全能化的；基质可以通过成骨细胞似神经轴突的胞浆突起传递，参与和促成另一细胞内基质的形成，提示这些基质可能含有信息物质；矿化可以发生在细胞内和细胞间，以细胞间的矿化为主；直接参与细胞间基质矿化的可能是一些小囊泡样基质，而较大的具质膜的球形基质则可能是其母体；均一的无定形基质成为类骨质的主要部分；基质的形成和分泌可能诱导了单核骨细胞融合形成破骨细胞，破骨细胞对基质的吞噬是有选择性的。作者认为基质可能在骨改建过程中，成骨细胞的成骨与破骨细胞的骨质吸收中起调节作用。
The types and the secreted state of human embryonic osteoblasts were observed in vitro using cell culture and morphological analysis, and the related problems were discussed. The results showed that the formation of spheres in different parts of osteoblasts And homogeneous amorphous matrix, suggesting that osteoblasts are omnipotent in the synthesis of the matrix; the matrix can be passed through the cytoplasm of osteoblast-like axons and participate in and contribute to the formation of another intracellular matrix, suggesting that these substrates May contain information material; mineralization can occur in cells and between cells, the main mineralization among cells; directly involved in the matrix of the matrix mineralization may be some small vesicle-like matrix, while the larger membrane The spherical matrix may be its parent; the homogeneous amorphous matrix becomes the major part of osteoid; the formation and secretion of matrix may induce the fusion of mononuclear bone cells to form osteoclasts, which are selective for substrate phagocytosis of. The authors believe that the matrix may play a regulatory role in the process of bone remodeling, osteoblast osteoblast and osteoclast bone resorption.