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谷胱甘肽过氧化物酶(GSH-Px。ECl。11。1。9)是一种含硒蛋白质,由4个相同的亚基构成,它以还原型谷胱甘肽为底物,催化还原H_2O_2和ROOH。 GSH-Px催化还原氢过氧化物的机理为乒乓机理,催化过程包括两个循环,其中B循环慢于A循环。Reich和Jasperse提出的关于有机硒模拟物的催化机理与天然酶的催化反应不同,反应过程中有氮原子的参与,本文合成的有机硒化合物Ⅰ、Ⅲ、Ⅳ为季铵盐型,氮原子无法参与催化反应过程中的成键及断键。因此,必须寻求新的反应机理。
Glutathione peroxidase (GSH-Px.ECl.11.1.9) is a selenoprotein composed of four identical subunits that catalyze the use of reduced glutathione as a substrate H_2O_2 and ROOH reduction. The mechanism of GSH-Px catalytic reduction of hydroperoxide is the ping-pong mechanism. The catalytic process consists of two cycles, of which the B cycle is slower than the A cycle. Reich and Jasperse suggested that the catalytic mechanism of organic selenium mimics is different from the catalytic reaction of natural enzymes. Nitrogen atoms are involved in the reaction. The organic selenium compounds I, III and IV synthesized in this paper are quaternary ammonium salts, Participate in the catalytic reaction of the key and the key. Therefore, we must seek a new reaction mechanism.