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目的研究血管内皮生长因子(VEGF)和可溶性受体(s Flt-1)与复发性流产之间的关系。方法回顾分析2013年4月至2015年4月妇产科收治的112例孕妇作为研究对象,按照孕妇是否为复发性流产患者分为人工流产组(对照组)55例和复发性流产组(观察组)57例,检测与记录两组患者VEGF和s Flt-1的表达水平,比较并探讨VEGF和s Flt-1表达对于检测复发性流产的临床意义。结果观察组血清中VEGF和s Flt-1的浓度显著高于对照组,观察组VEGF和s Flt-1在绒毛组织中表达情况为阳性的比例均显著高于对照组,差异均有统计学意义(均P<0.05);s Flt-1/VEGF比值越大,患者进行流产手术的时间越短。结论 VEGF和s Flt-1的浓度对于孕期复发性流产的诊断和预防有重要意义,复发性流产患者体内VEGF和s Flt-1的表达水平显著高于正常人,VEGF/s Flt-1的值越大越应该得到重视,应及时就医。
Objective To investigate the relationship between vascular endothelial growth factor (VEGF) and soluble receptor (s Flt-1) and recurrent spontaneous abortion. Methods A total of 112 pregnant women admitted to obstetrics and gynecology from April 2013 to April 2015 were retrospectively analyzed. According to whether pregnant women were recurrent spontaneous abortion, 55 cases were divided into abortion group (control group) and recurrent spontaneous abortion group (observation group Group) 57 cases, detection and recording of VEGF and s Flt-1 expression levels in both groups, to compare and explore the clinical significance of VEGF and s Flt-1 expression for the detection of recurrent spontaneous abortion. Results The serum concentrations of VEGF and s Flt-1 in the observation group were significantly higher than those in the control group. The positive rates of VEGF and s Flt-1 in the observation group were significantly higher than those in the control group, the differences were statistically significant (All P <0.05). The greater the s Flt-1 / VEGF ratio, the shorter the duration of abortion. Conclusions The concentrations of VEGF and s Flt-1 are of great significance for the diagnosis and prevention of recurrent spontaneous abortion during pregnancy. The expression of VEGF and s Flt-1 in patients with recurrent spontaneous abortion is significantly higher than that of normal people and VEGF / s Flt-1 The bigger the more should be paid attention, should seek medical treatment promptly.