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目的:探讨CD4T淋巴细胞、CD8T淋巴细胞及IL-7在丙肝病毒(HCV)单纯感染,艾滋病病毒(HIV)单纯感染和HCV/HIV合并感染过程中的表达及意义。方法:采用流式细胞术,检测HCV感染组,HIV感染组,HCV/HIV感染组及正常对照组人外周血CD4T淋巴细胞、CD8T淋巴细胞计数及IL-7水平。结果:HIV感染组及HCV/HIV合并感染组CD4T细胞计数明显下降(P<0.001),IL-7明显升高;HCV感染组IL-7也明显升高。结论:河南省HCV/HIV合并感染患者外周血CD4 T淋巴细胞下降,IL-7明显升高。
Objective: To investigate the expression and significance of CD4 T lymphocyte, CD8 T lymphocyte and IL-7 in the process of simple infection with hepatitis C virus (HCV), simple infection with HIV and HCV / HIV infection. Methods: The levels of CD4 T lymphocyte, CD8 T lymphocyte count and IL-7 in peripheral blood of HCV infected group, HIV infected group, HCV / HIV infected group and normal control group were detected by flow cytometry. Results: The counts of CD4 T cells in HIV infected group and HCV / HIV co-infected group were significantly decreased (P <0.001), IL-7 was significantly increased, and the level of IL-7 in HCV-infected group was significantly higher. Conclusion: The CD4 T lymphocytes in peripheral blood of patients with HCV / HIV co-infection in Henan Province decreased and the level of IL-7 increased significantly.