吗丁啉是一种新型胃动力药,其锥体外系副作用较为罕见。笔者曾遇一例由于口服吗丁啉致扭转性痉挛的患者,现报道如下。 患者李××,男,20岁。因腹泻、恶心、呕吐1d于1993年8月13日就诊。诊断为“急性胃肠炎”。给10%氯化钾液10ml口服3次/d;ORS补液盐1包冲服3次/d;庆大霉素8万u口服3次/d;吡哌酸0.5口服3次/d;吗丁啉10mg口服3次/d。病人第一次服药后4小时,即出现发作性头颈躯干缓慢扭转,每次数分钟,约1小时发作一次,即来院就诊。既往健康,无药物过敏史。查体:体温、脉搏、呼吸、血压均正常,神志清楚,脑神经无异常,四肢肌力、肌张力正常,感觉、共济无异常,双病理征 Domperidone is a new gastric motility drug, its extrapyramidal side effects are relatively rare. I have encountered a case due to oral morphine induced torsion spasm in patients are reported below. Patient Lee × ×, male, 20 years old. Due to diarrhea, nausea, vomiting 1d on August 13, 1993 treatment. Diagnosed as “acute gastroenteritis.” To 10% potassium chloride solution 10ml orally 3 times / d; ORS rehydration salt 1 package blunt 3 times / d; gentamicin 80,000 u oral 3 times / d; Pipemidic acid 0.5 orally 3 times / d; 10mg orally 3 times / d. 4 hours after the patient took the first dose of the drug, there was a slow turn of the epiphysis of the head and neck torso. Every few minutes, an attack took about 1 hour to see a doctor. Past health, no history of drug allergy. Physical examination: body temperature, pulse, respiration, blood pressure were normal, conscious, no abnormalities of the cranial nerves, muscle strength, normal muscle tone, sensory, mutual aid normal, double pathological signs