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目的：用一氯氮合成酶（ＮＯＳ）抑制剂 ＮＧ－硝基－左旋－精氨酸甲脂（Ｌ－ＮＡＭＥ）兔耳静脉注入，观察Ｌ－ＮＡＭＥ对家兔脊髓缺血再灌流损伤后脊髓血流量（ＳＣＢＦ）的影响．方法：采用肾动脉下腹主动脉（ＩＲＡ）阻断方法将动物分为两组：对照组和治疗组，观察时相１５ｍｉｎ、３０ｍｉｎ、１ｈ、２ｈ、４ｈ、６ｈ．结果：治疗组与脊髓缺血再灌流损伤比较，再灌流后１５ｍｉｎ和６ｈ脊髓灰质血流量（ＳｇＢＦ）有显著升高（Ｐ＜０．０１）；再灌流后３０ｍｉｎ、１ｈ、２ｈ、４ｈ虽然ＳＣＢＦ比损伤组有升高，但无统计学意义．治疗组再灌流后１５ｍｉｎ脊髓白质（ＳｗＢＦ）显著升高（Ｐ＜０．０１）．结论：选用ＮＯＳ抑制剂Ｌ－ＮＡＭＥ对脊髓缺血再灌流损伤ＳＣＢＰ具有改善作用．
OBJECTIVE: To observe the effects of L-NAME on the spinal cord after spinal cord ischemia-reperfusion injury in rabbits by injecting NG-nitro-L-arginine methyl ester (L-NAME) Blood flow (SCBF) effects. Methods: The animals were divided into two groups according to the method of blocking the abdominal aorta (IRA) of the renal artery: the control group and the treatment group. The observation time was 15min, 30min, 1h, 2h, 4h, 6h. Results: Compared with spinal cord ischemia-reperfusion injury, the spinal cord gray matter blood flow (SgBF) increased significantly (P <0.01) at 15 min and 6 h after reperfusion in rats. At 30 min, 1 h, 2 h and 4 h after reperfusion, SCBF Than the injury group increased, but not statistically significant. Spinal cord white matter (SwBF) was significantly increased 15 min after reperfusion in treatment group (P <0.01). Conclusion: The use of NOS inhibitor L-NAME can improve SCBP after spinal cord ischemia-reperfusion injury.