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采用后接枝法制备了席夫碱铜离子配合物改性凹凸棒土(Cu2+-Sal-ATP),通过浸渍法制备了啶虫脒/凹凸棒土(ATP)缓释体系。利用FTIR、XRD、N2吸附-脱附、SEM和DSC对改性凹凸棒土的结构和性质进行了表征,考察了改性凹凸棒土对农药啶虫脒的吸附行为和缓释体系的释药行为。结果表明:啶虫脒是以非晶相存在于改性凹凸棒土中,药物装载未改变载体的结构。有机改性提高了凹凸棒土对药物的吸附量,经席夫碱铜离子配位改性体系的吸附量最高,为34.17 mg/g,且吸附行为符合准二级动力学模型。Cu2+-Sal-ATP载药体系的缓释效果优于相应的席夫碱改性凹凸棒土(Sal-ATP)体系,其药物在168 h的累积释放率由23.41%降低至19.42%,且其释药行为可用Korsmeyer-Pappas动力学模型来描述。
The Cu2 + -Sal-ATP modified Schiff base copper ion complex was prepared by post-grafting method. The acetochitidine / attapulgite (ATP) sustained release system was prepared by impregnation method. The structure and properties of modified attapulgite were characterized by FTIR, XRD, N2 adsorption-desorption, SEM and DSC. The adsorption behavior of modified attapulgite to acetamiprid and the release of the sustained-release system were investigated. behavior. The results showed that acetamiprid was present in the modified attapulgite as an amorphous phase, and the drug loading did not change the structure of the carrier. Organic modification increased the amount of drug adsorbed on attapulgite. The adsorption capacity of the system was 34.17 mg / g, which was in accordance with quasi-second-order kinetic model. The sustained-release effect of Cu2 + -Sal-ATP system was better than that of the corresponding Schiff base modified attapulgite (Sal-ATP) system. The cumulative release rate of Cu2 + -Sal-ATP from 23.41% to 19.42% Drug release behavior Korsmeyer-Pappas kinetic model can be used to describe.