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卡马西平是临床上常用的抗癫痫药,常与多种抗癫痫药合用,在药物代谢上彼此影响血药浓度,且多数抗癫痫药均具有肝酶诱导作用,使药物的 t1/2缩短,从而降低血药浓度。因此监测血药浓度,随时调整给药剂量,对提高疗效和减少毒副反应具有重要意义。目前卡马西平的测定有气相色谱法、光谱法、薄层色谱法和高效液相色谱法等,本文用反相 HPLC 法测定了卡马西平血药浓度,方法简便,结果可靠、准确。药品与试剂:卡马西平由南京军区总院提供;安定,自行精制;乙醚 AR,上海马陆制药厂;甲醇 GR,上海吴经化工厂。仪器和色谱条件:Backman 344 M HPLC 仪,165UV
Carbamazepine is commonly used in clinical antiepileptic drugs, often with a variety of antiepileptic drugs in the drug metabolism affect each other blood concentration, and most of the antiepileptic drugs have liver enzyme induction, the drug shortening t1 / 2 , Thereby reducing blood concentration. Therefore, monitoring blood concentration, adjust the dose at any time, to improve the efficacy and reduce toxicity is of great significance. Carbamazepine currently available for determination of gas chromatography, spectroscopy, thin-layer chromatography and high performance liquid chromatography, the determination of the concentration of carbamazepine by reverse phase HPLC method, the method is simple, the results are reliable and accurate. Drugs and Reagents: Carbamazepine is provided by Nanjing Military Region General Hospital; stability and self-purification; ether AR, Shanghai Malu Pharmaceutical Factory; methanol GR, Shanghai Wujing Chemical Plant. Equipment and chromatographic conditions: Backman 344 M HPLC instrument, 165 UV