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目的 :为了解先天性巨结肠症患儿性激素水平变化有无异常 ,我们对先天性巨结肠症男性患儿性激素水平进行了观测。方法 :共 2 6例先天性巨结肠症男性患儿 ,经病史 ,体征及钡灌肠结果确定诊断 ,年龄出生后 2 0天到 18岁 ,平均年龄 2 0岁 ,同时取 2 6例正常同龄儿为对照 ,共 5 2例。样本均采肘静脉或股静脉 3ml ,离心血清 ,抗原放免测定 ,测定项目包括黄体生成素 (LH) ,卵泡刺激素 (FSH) ,睾丸酮 (T)。结果 :各年龄组先天性巨结肠症患儿与正常同龄儿T、FSH、LH变化大致平行 ,各年龄组与正常同龄儿无显著差异 ,P >0 0 5。 6岁前先天性巨结肠症患儿各年龄组血清T水平稳定在 0 0 1ng/ml,血清FSH水平呈现逐渐上升趋势 ,血清LH水平拉于1 0 2IU/L到 1 3 2IU/L之间 ,6岁后T、FSH、LH水平逐渐上升 ,到 8岁时血清T为 3 10ng/ml ,血清FSH为 5 2 2IU/L ,血清LH为 4 2 2IU/L。结论 :观察结果表明 18岁以内各年龄患儿性激素水平与正常同龄儿无显著差异 ,可以认为自患儿出生到 18岁以内先天性巨结肠症患儿性激素水平无异常 ,没有充分理由认为性激素水平异常构成了先天性巨结肠症的病因。有关先天性巨结肠症中发病人群性修饰现象尚需进一步研究。
OBJECTIVE: To investigate the changes of sex hormones in children with Hirschsprung’s disease, we investigated the levels of sex hormones in children with Hirschsprung’s disease. Methods: A total of 26 male Hirschsprung’s disease patients were diagnosed according to their medical history, signs and barium enema results. The average age was 20 years old after birth and 20 normal children As a control, a total of 52 cases. Samples were collected cubital vein or femoral vein 3ml, centrifuged serum, antigen radioimmunoassay, measurement items include luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T). Results: The changes of T, FSH and LH in children with Hirschsprung ’s disease of all age groups were similar to those of normal children. There was no significant difference between each age group and normal children (P> 0.05). Serum levels of T in children with Hirschsprung’s disease before 6 years of age were stable at 0 0 1 ng / ml, serum FSH levels showed a gradual upward trend, serum LH levels were pulled between 102 IU / L and 132 IU / L After 6 years of age, the levels of FSH and LH increased gradually. By the age of 8 years, serum T was 3 10 ng / ml, serum FSH 522 IU / L and serum LH 4212 IU / L. CONCLUSIONS: The results of the observation indicate that there is no significant difference in sex hormones between children under 18 years of age and normal peers, and it can be considered that there is no abnormalities in sex hormone levels in children with Hirschsprung’s disease from birth to 18 years of age, and there is no sufficient reason to consider sex hormone levels Abnormal constitute the etiology of Hirschsprung disease. The incidence of Hirschsprung disease in human sexual modification needs further study.