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Objective: To compare the cognitive and behavioural effects of unilateral pall idotomy and bilateral subthalamic nucleus (STN)stimulation. Methods: After basel ine examination 34 patients were randomly assigned to unilateral pallidotomy (4 left-sided,10 right-sided) or bilateral STN stimulation (n=20). At baseline an d six and twelve months after surgery we administered neuropsychological tests o f language, memory, visuospatial function, mental speed and executive functions. Also a depression rating scale, and self and proxy ratings of memory and dysexe cutive symptoms were administered. Results: Six months after surgery, the STN gr oup and the pallidotomy group differed significantly in change from baseline in number of errors on two tests of executive functioning. After 12 months the STN group reported less positive affect compared with baseline than the pallidotomy group. One patient in the STN group showed an overall cognitive deterioration du e to complications.Conclusions: Although we need larger groups to draw firm conc lusions, our results suggest that bilateral STN stimulation has slightly more ne gative effects on executive functioning than unilateral pallidotomy.
Objective: To compare the cognitive and behavioral effects of unilateral pall idotomy and bilateral subthalamic nucleus (STN) stimulation. Methods: After basel ine examination 34 patients were randomly assigned to unilateral pallidotomy (4 left-sided, 10 right-sided) or bilateral STN stimulation (n = 20). At baseline an d six and twelve months after surgery we administered neuropsychological tests of language, memory, visuospatial function, mental speed and executive functions. Also a depression rating scale, and self and proxy ratings of memory and dysexe Results: Six months after surgery, the STN gr oup and the pallidotomy group differed significantly in change from baseline in number of errors on two tests of executive functioning. After 12 months the STN group reported less positive affect compared with baseline than the pallidotomy group. One patient in the STN group showed an overall cognitive deterioration du e complications. Conlusions: Altho ugh we need larger groups to draw firm conc lusions, our results suggest that bilateral STN stimulation has slightly more ne gative effects on executive functioning than unilateral pallidotomy.