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M_4Eo是伴有骨髓嗜酸性粒细胞增多的一类急性粒-单核细胞白血病,其主要特点是在骨髓中出现形态学、细胞化学异常的嗜酸性粒细胞及细胞遗传学染色体核型有16号染色体的特殊改变。M_4Eo从临床和形态学上作为白血病的一种独立亚型已渐为人们所接受。1978年Stavem等首先发现本病,并作了报道。其后1982年Arthur等人报告5例,正式命名为M_4Eo。至1986年止,国外报告已达136例。且有增多的趋势。1984年FAB协作组将本病列为急性粒-单核细胞白血病的一个特殊亚型。本病的染色体的特殊改变于1982年第四次国际白血病染色体讨
M_4Eo is associated with bone marrow eosinophilia of a group of acute myelomonocytic leukemia, which is characterized by the main morphological and cytochemical abnormalities in bone marrow eosinophils and cytogenetic chromosome karyotype 16 Chromosomal special changes. M_4Eo has been clinically and morphologically as an independent subtype of leukemia has been gradually accepted. Stavem first discovered the disease in 1978, and made a report. Arthur et al. Then reported 5 cases in 1982, officially named M_4Eo. As of 1986, foreign reports have reached 136 cases. And there is an increasing trend. In 1984, FAB collaborated group classified this disease as a special subtype of acute granulocyte-monocytic leukemia. The chromosomal changes of the disease in 1982 the fourth international leukemia chromosome discussion