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目的观察骨巨细胞瘤Ｊａｆｆｅ组织分级与瘤细胞增殖的关系。方法应用免疫组化ＡＢＣ法对２７例不同组织级别的骨巨细胞瘤进行增殖细胞核抗原（ＰＣＮＡ）检测。结果ＰＣＮＡ的阳性反应仅见于基质细胞的胞核中，多核巨细胞呈阴性反应。不同组织级别的骨巨细胞瘤之间，ＰＣＮＡ阳性检出率无显著差别（Ｐ＞０．０５）。结论骨巨细胞瘤Ｊａｆｆｅ分级系统与肿瘤细胞的增殖情况无关；多核巨细胞非肿瘤细胞。
Objective To observe the relationship between the grade of Jaffe tissue and the proliferation of tumor cells in giant cell tumor of bone. Methods The proliferating cell nuclear antigen (PCNA) was detected in 27 giant cell tumors with different histological grade using immunohistochemical ABC method. Results The positive reaction of PCNA was only found in the nucleus of stromal cells, and the multinucleated giant cells were negative. There was no significant difference in the positive detection rate of PCNA between different tissue grades of giant cell tumor of bone (P>0.05). Conclusion The Jaffe grading system of giant cell tumor of bone has nothing to do with the proliferation of tumor cells; multinucleated giant cells are non-tumor cells.