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目的评价葡萄糖酸锌喷鼻剂预防急性上呼吸道感染的效果。方法使用随机双盲安慰剂对照方法,选择河北省廊坊市卫生学校学生,随机分成药物组和安慰剂组,观察2个月,使用卡方检验比较急性上呼吸道感染和流感样病例的人时发病率。结果共有1945名学生合格完成调查表格,用药组978人,安慰剂组967人。急性上呼吸道感染发病率用药组为14人/100人月,安慰剂组为20人/100人月,差别有统计学意义(χ2=12,P<0.01)。流感样病例发病率用药组为0.2人/100人月,安慰剂组为1.8人/100人月,差别有统计学意义(χ2=12,P<0.01)。结论葡萄糖酸锌喷鼻剂对上呼吸道感染具有一定程度的预防效果。
Objective To evaluate the efficacy of zinc gluconate nasal spray in preventing acute upper respiratory tract infection. Methods A randomized, double-blind, placebo-controlled study was conducted to select health school students in Langfang City, Hebei Province, randomly divided into medication group and placebo group. The patients were observed for 2 months and compared with those of patients with acute upper respiratory tract infection and influenza-like illness by chi-square test rate. Results A total of 1945 students completed the questionnaire, 978 in the medication group and 967 in the placebo group. The incidence of acute upper respiratory tract infection was 14/100 in the drug-treated group and 20/100 in the placebo group. The difference was statistically significant (χ2 = 12, P <0.01). The incidence of influenza-like illness was 0.2 / 100 person-months in the treatment group and 1.8 / 100 person-months in the placebo group, with a significant difference (χ2 = 12, P <0.01). Conclusion The zinc gluconate nasal spray has a certain degree of preventive effect on upper respiratory tract infection.