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Many malignancies lack satisfactory treatment and new therapeutic options are urgently needed.Gene therapyis a new modality to treat both inherited and acquired diseases based on the transfer of genetic material to thetissues.Different gene therapy strategies against cancers have been developed.A considerable number ofpreclinical studies indicate that a great variety of cancers are amenable to gene therapy.Among these strategies,induction of anti-tumor immunity is the most promising approach.Gene therapy with cytokines has reachedunprecedented success in preclinical models of cancer.Synergistic rather than additive effects have beendemonstrated by combination of gene transfer of cytokines/chemokines,costimulatory molecules or adoptivecell therapy.Recent progress in vector technology and in imaging techniques allowing in vivo assessment ofgene expression will facilitate the development of clinical applications of gene therapy,a procedure which mayhave a notorious impact in the management of cancers lacking effective treatment.Cellular & MolecularImmunology.2004;1(2):105-111.
Many malignancies lack satisfactory treatment and new therapeutic options are urgently needed. Gene therapy a new modality to treat both inherited and acquired diseases based on the transfer of genetic material to the tissues. Diverse gene therapy strategies against cancers have been developed. A considerable number of preclinical studies Expression that a great variety of cancers are amenable to gene therapy. Among these strategies, induction of anti-tumor immunity is the most promising approach. Gene therapy with cytokines has reachedunprecedented success in preclinical models of cancer. Synergistic rather than additive effects have been demonstrated combination of gene transfer of cytokines / chemokines, costimulatory molecules or adoptive cell therapy. Recent progress in vector technology and in imaging techniques allowing in vivo assessment of gene expression will facilitate the development of clinical applications of gene therapy, a procedure which mayhave a notorious impact in the managemen t of cancers lacking effective treatment. Cellular & Molecular Immunology. 2004; 1 (2): 105-111.