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在水相中,以水杨醛和卡巴肼为原料,室温下高产率合成了1-(2-羟基苯亚甲基)卡巴肼(3),随后以乙醇/冰醋酸为混合溶剂、微波功率为350 W、温度为120℃和其他芳香醛/酮反应16~30 min得到1,5-二取代卡巴肼衍生物4a~4p,并用IR、1H NMR、13C NMR和元素分析对其结构进行了表征.与传统的方法相比,该法具有简单、快速、高效和对环境友好等优点,为不对称双席夫碱的合成提供一定的参考.X射线衍射分析表明化合物4i属于单斜晶系,P21/c空间群.
In the aqueous phase, 1- (2-hydroxybenzylidene) carbazide (3) was synthesized with salicylaldehyde and carbohydrate hydrazide at high yield at room temperature, followed by ethanol / glacial acetic acid as a mixed solvent, microwave power 1,5-disubstituted carbazide derivatives 4a ~ 4p were obtained at 350 W, 120 ℃ and 16 ~ 30 min reaction with other aromatic aldehydes / ketones and their structures were characterized by IR, 1H NMR, 13C NMR and elemental analysis Characterization.Compared with the traditional method, this method has the advantages of simple, rapid, efficient and environment-friendly, and provides some reference for the synthesis of asymmetric Schiff bases.X-ray diffraction analysis showed that compound 4i belongs to the monoclinic system , P21 / c space group.