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目的 :探讨内源性一氧化氮 (NO)在新生儿缺氧缺血性脑病 (HIE)中的作用 ;方法 :观察 30例HIE患儿 (轻度 1 0例 ,中度 1 5例 ,重度 5例 )急性期及恢复期血浆NO水平 ,并与 2 6例正常新生儿进行比较 ;结果 :HIE急性期患儿血浆NO水平除轻度组外 ,中、重度组明显高于对照组 ,重度组明显高于轻度组 ,恢复期 3组血浆NO水平平均降至接近正常 ,与对照组比较 ,差异无显著意义 ;结论 :NO在新生儿HIE发病过程中具有重要意义。
Objective: To investigate the role of endogenous nitric oxide (NO) in neonatal hypoxic-ischemic encephalopathy (HIE). Methods: Thirty HIE children (mild to moderate or severe HIE) 5) acute and convalescent plasma NO levels and compared with 26 normal neonates; Results: In addition to the mild group, the levels of NO in the plasma of HIE patients were significantly higher than those in the mild and moderate groups Group was significantly higher than the mild group, the recovery of plasma NO levels in the three groups averaged close to normal, with no significant difference compared with the control group; Conclusion: NO in neonatal HIE pathogenesis is of great significance.