作为重要的四碳平台化合物,琥珀酸被美国能源部列为12种最具潜力的大宗生物基化学品之首.CO_2作为琥珀酸合成的必需底物,是决定琥珀酸合成效率的关键因素.本文从CO_2溶解、转运及转化、固定和组合调控4个方面系统评述了琥珀酸生物合成过程中CO_2代谢调控的研究进展,并探讨了CO_2调控策略的未来发展方向. As an important four-carbon platform compound, succinic acid is ranked as the 12 most promising bulk bio-based chemicals by the US Department of Energy.CO 2, an essential substrate for the synthesis of succinate, is the key factor that determines the efficiency of succinate synthesis. In this paper, we reviewed the research progress of CO 2 metabolism in succinic acid biosynthesis from four aspects of CO 2 dissolution, transport and transformation, fixation and combination regulation, and discussed the future development direction of CO 2 regulation strategy.