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对于光镜下肾组织形态正常的肾病综合征病人,其系膜区内IgM沉积物是否具有重要性,一直存在争论。这些沉积物的存在是否标志一种特殊的临床疾病,抑或他们的出现仅仅意味着是微小病变肾病的一种变异?此外,在没有肾病综合征的蛋白尿及/或血尿患者中,这些沉积物的存在又有什么意义? 人们对肾病综合征的形态学的了解主要是依据国际性儿童肾病综合征的研究。这项大系列的研究工作完全是根据光镜检查的结果,并没有将免疫荧光检查的发现联系起来。虽然有一些研究单位曾各自尝试在小组病例中观察这些免疫沉积物的临床意义,但病例数目都没有超过30～40例。
There is controversy over the importance of IgM deposits in the mesangial area for patients with nephrotic syndrome whose morphology is normal under light microscopy. Does the presence of these deposits signify a particular clinical disease, or does their presence merely mean a variant of minimal change nephropathy? In addition, in patients with nephrotic syndrome and without proteinuria and / or hematuria, these deposits What is the significance of the existence? People’s understanding of the morphology of nephrotic syndrome is mainly based on the international study of children with nephrotic syndrome. This large series of studies is based purely on light microscopy and does not link the findings of immunofluorescence. Although some research institutes have each tried to observe the clinical significance of these immune deposits in a small group of patients, no more than 30 to 40 cases were reported.