论文部分内容阅读
目的 :利多卡因与氟桂利嗪治疗偏头痛近期疗效比较。方法 :偏头痛病人 69例 ,随机分为 2组。利多卡因组 :用利多卡因 1 2mg/kg加入 5 0 %G·S 10ml静注 ,4～ 6min注完 ,qd ,连用 3d。氟桂利嗪组 :用氟桂利嗪胶囊 2粒 ( 5mg/粒 ) ,po ,qd ,用药 3d。结果 :利多卡因组显效率 74 3 %,总有效率 91 4%,氟桂利嗪组显效率 5 2 9%,总有效率 91 2 %,2组间显效率存在差异 (P <0 0 5 ) ,总有效率无显著差异 (P >0 0 5 )。 2组用药后起效时间 ,利多卡因组 0 4± 0 3d ,氟利桂嗪组是 1 5± 0 8d ,P <0 0 1。结论 :两药治疗偏头痛近期总疗效近似 ,但利多卡因组比氟桂利嗪组显效比例高 ,作用明显迅速 ,利多卡因可作为急诊控制偏头痛的有效药物。
OBJECTIVE: To compare the short term efficacy of lidocaine and flunarizine in the treatment of migraine. Methods: 69 migraine patients were randomly divided into two groups. Lidocaine group: Lidocaine 1 2mg / kg added 50% G · S 10ml intravenous injection, 4 ~ 6min note finished, qd, even 3d. Flunarizine group: Flunarizine capsules 2 (5mg / tablets), po, qd, medication 3d. Results: The effective rate of lidocaine group was 74.3%, the total effective rate was 91.4%, the effective rate of flunarizine group was 52.9%, the total effective rate was 91.2%, there was significant difference between two groups (P <0 0 5), the total effective rate was not significantly different (P> 0 0 5). The onset time of the two groups was 0 4 ± 0 3d in the lidocaine group and 15 ± 0 8d, respectively, P <0.01. Conclusion: The overall efficacy of the two drugs in the treatment of migraine is similar in the near future. However, the effect of lidocaine is obviously higher than that of flunarizine, and the effect is obvious. Lidocaine can be used as an effective drug in the control of migraine.