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OBJECTIVE To analyze the serum levels of IgA antibodies toEpstein Barr virus capsid antigens(EBV/IgA/VCA)in patientswith nasopharyngeal carcinoma(NPC)and in their spouses andchildren in order to further evaluate the risk of developing thedisease in family members of NPC patients.METHODS Four categories of sera were used to detect EBV/IgA/VCA using the immunoenzyme method.In our study 317biopsy-confirmed NPC patients,317 spouses and 317 children ofthe NPC patients,as well as 413 healthy subjects as the controlsthat came from the same area were enrolled.RESULTS The positive rate of EBV/IgA/VCA was 97.2%,14.2%,19.9% and 3.1% in the NPC patients,the spouse and child groups,and in the control group,respectively.The positive rate wassignificantly higher in the NPC group than in the other 3 groups,and it was also significantly higher in the spouse and in the childgroups than in the control group(P<0.001).The results of therelative to identified distribution unit(Ridit)analysis showedthat the average Ridit values were 0.860,0.404,0.424 and 0.356respectively in the NPC patients,in the spouse and child groups,and in the control group.The antibody titer of IgA/VCA wassignificantly higher in the NPC group than in the other 3 groups,and it was also significantly higher in both the spouse and childgroups than in the control group(P<0.001).The OR values ofpositive EBV/IgA/VCA antibody were 5.09 and 7.63,respectivelyin the spouse and child groups.No significant differences werefound in the positive rates or in the titers of IgA/VCA antibodybetween the groups of spouses and children(P>0.05).CONCLUSION Positive detection of EBV/IgA/VCA antibodyoccurs in familial aggregation,as there is ample opportunityfor EBV reactivation in the spouses and in the children of NPCpatients.These individuals with a high risk of developing theNPC should be closely followed in order to detect the disease atan early stage.
OBJECTIVE To analyze the serum levels of IgA antibodies to Epstein Barr virus capsid antigens (EBV / IgA / VCA) in patients with nasopharyngeal carcinoma (NPC) and in their spouses and children in order to further evaluate the risk of developing the disease in family members of NPC patients. METHODS Four categories of sera were used to detect EBV / IgA / VCA using the immunoenzyme method. In our study 317 biopsy-confirmed NPC patients, 317 spouses and 317 children of the NPC patients, as well as 413 healthy subjects as the control case came from the same The areas were enrolled .RESULTS The positive rate of EBV / IgA / VCA was 97.2%, 14.2%, 19.9% and 3.1% in the NPC patients, the spouse and child groups, and in the control group, respectively.The positive rate wassignificantly higher in the NPC group than in the other 3 groups, and it was also significantly higher in the spouse and in the childgroups than in the control group (P <0.001). The results of therelative to identified distribution unit (Ridit) analysis showedthat the average Ridit values were 0.860, 0.404, 0.424 and 0.356 respectively in the NPC patients, in the spouse and child groups, and in the control group. The antibody titer of IgA / VCA wassignificantly higher in the NPC group than in the other 3 groups, and it was also significantly higher in both the spouse and childgroups than in the control group (P <0.001). The OR values of positive EBV / IgA / VCA antibody were 5.09 and 7.63, respectively in the spouse and child groups. No significant differences were found in in the positive rates or in the titers of IgA / VCA antibodybetween the groups of spouses and children (P> 0.05) .CONCLUSION Positive detection of EBV / IgA / VCA antibodyoccurs in familial aggregation, as there is ample opportunity for EBV reactivation in the spouses and in the children of NPCpatients.These individuals with a high risk of developing theNPC should be closely followed in order to detect the disease atan early stage.