论文部分内容阅读
目的 探讨SARS的病理形态学特点。方法 常规HE染色,光镜观察。免疫组化S-P法检测3例SARS患者的肺组织CK、CD34、Ⅳ型胶原、CD 68、Mac 387的表达。结果 SARS病理形态表现为肺泡上皮广泛破坏,Ⅱ型上皮细胞增生。肺泡壁毛细血管内皮细胞肿胀。大部分肺泡腔及肺泡管内透明膜形成。间质有较多的炎症细胞浸润,纤维母细胞增生。结论 SARS是一种伴透明膜形成的急性非特异性间质性肺炎。
Objective To investigate the pathomorphological features of SARS. Methods routine HE staining, light microscopy. The expression of CK, CD34, type Ⅳ collagen, CD68, Mac 387 in lung tissue of 3 SARS patients was detected by immunohistochemical S-P method. Results The pathological changes of SARS were extensive destruction of alveolar epithelium and type Ⅱ epithelial cell hyperplasia. Alveolar wall capillary endothelial cell swelling. Most of the alveolar space and the alveolar membrane of the transparent membrane formation. Interstitial infiltration of inflammatory cells, fibroblasts proliferation. Conclusion SARS is an acute nonspecific interstitial pneumonia with transparent membrane formation.