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目的探讨高脂血症急性胰腺炎(HLAP)的临床特征及治疗。方法回顾性分析2011年3月至2013年12月期间在笔者所在医院治疗的25例HLAP患者的临床资料,并与同期128例胆源性胰腺炎(ABP)患者进行对比研究。结果 HLAP组患者年龄偏年轻、男性多于女性,在体质量指数、合并糖尿病的比例、复发率、病情严重程度及血糖上明显高于ABP组(P<0.05),甘油三酯明显升高(P<0.01);ABP组血尿淀粉酶水平较HLAP组明显升高(P<0.05)。结论 HLAP多发生于年轻的男性肥胖患者,常合并有糖尿病,具有重症胰腺炎发病率高、血甘油三酯高和血尿淀粉酶低的不同于ABP的临床特点。采用血液净化等治疗,可降低其病死率。
Objective To investigate the clinical characteristics and treatment of hyperlipidemic acute pancreatitis (HLAP). Methods The clinical data of 25 patients with HLAP treated in our hospital from March 2011 to December 2013 were analyzed retrospectively and compared with 128 patients with biliary pancreatitis (ABP) during the same period. Results The patients in HLAP group were younger than men and older than those in women. The body mass index, the proportion of diabetes mellitus, relapse rate, severity of illness and blood glucose in HLAP group were significantly higher than those in ABP group (P <0.05) and triglyceride P <0.01). The level of hematuria amylase in ABP group was significantly higher than that in HLAP group (P <0.05). Conclusions HLAP occurred mostly in young male obese patients, often with diabetes mellitus, with a high incidence of severe pancreatitis, high blood triglyceride and hematuria, low amylase clinical features different from ABP. Treatment with blood purification can reduce its mortality.