2例患者因慢性乙型肝炎(乙肝)长期接受阿德福韦酯(ADV) 10 mg/d治疗出现肢体疼痛,全身乏力.例1为58岁男性患者,例2为55岁女性患者,实验室检查血磷分别为0.71和0.58mmol/L,24 h尿磷分别为6.82和4.57 mmol/24 h；关节部位X线检查均显示骨质疏松；骨扫描检查示放射性物质摄取增高,诊断为低血磷性骨病.例1肌电图检查提示有周围神经受累,考虑低血磷性骨病并发周围神经病.继续服用阿德福韦酯情况下,给予补充磷酸盐治疗及食用富含磷酸盐食物,患者症状均有改善.“,”Two patients with chronic hepatitis B developed limb pain and asthenia after receiving adefovir dipivoxil (ADV) 10 mg/d.Patient 1 were male aged 58,patient 2 were female aged 55.Laboratory tests revealed that serum phosphorus levels in patients 1 and 2 were 0.71 and 0.58 mmol/L,respectively;24-hour urinary phosphorus levels in patients 1 and 2 were 6.82 and 4.57 mmo]/24 h,respectively.Joint X-ray showed osteoporosis; a bone scan revealed increased radiotracer uptake.The 2 patients were diagnosed with hypophosphatemic bone disease.Electromyography showed peripheral nerve damage in patient 1 and he was considcred to have hypophosphatemic bone disease complicated with peripheral neuropathy.Adefovir dipivoxil was continued,supplementary phosphate and phosphorus-rich foods were given,their symptoms improved.