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胆囊收缩素 (CCK)是一种脑肠肽 ,作为胃肠激素和神经肽 ,其分布广泛 ,通过受体介导多种重要的生理功能。CCK受体激动剂与拮抗剂的研究深入 ,促进了人们对CCK生理功能的深入认识。CCK通过内分泌、旁分泌、神经分泌、自分泌等途径发挥生理作用。作者从CCK与胃肠运动、胰液分泌、胃酸分泌、胰腺生长的关系以及CCK作为肠抑胃素、饱因子6个方面综述CCK对消化功能的影响及其相关机制。
Cholecystokinin (CCK) is a ghrelin that acts as a gastrointestinal hormone and neuropeptide and is widely distributed to mediate a variety of important physiological functions through receptors. CCK receptor agonists and antagonists in-depth study, and promote people’s understanding of the physiological functions of CCK. CCK through the endocrine, paracrine, neurosecretory, autocrine and other ways to play a physiological role. The author summarizes the effects of CCK on digestive function and its related mechanisms from the aspects of CCK and gastrointestinal motility, pancreatic secretion, gastric acid secretion, pancreatic growth and CCK as enterokinase and full factor.