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目的对不同剂量的米非司酮在妊娠8~10周流产中的临床应用效果予以探讨。方法 72例妊娠8~10周流产患者随机分为对照组与观察组,各36例。对照组患者应用150 mg米非司酮治疗,观察组患者应用300 mg米非司酮治疗,两组患者均配合服用米索前列醇,对两组患者的临床治疗效果及不良反应的发生情况予以对比分析。结果两组患者的不良反应发生情况比较,差异无统计学意义(P>0.05);观察组患者的胚胎排出时间短于对照组,流产有效率高于对照组患者,差异具有统计学意义(P<0.05)。结论在妊娠8~10周流产患者的治疗过程中,应用300 mg的米非司酮流产率更高,并且胚胎的排出时间明显缩短,不会增大患者的不良反应发生率,值得在临床推广。
Objective To investigate the clinical effects of different doses of mifepristone in abortion at 8-10 weeks gestation. Methods Seventy-two cases of abortion with pregnancy of 8-10 weeks were randomly divided into control group and observation group, with 36 cases in each group. Patients in the control group were treated with 150 mg of mifepristone, while patients in the observation group were treated with 300 mg of mifepristone. Patients in both groups were given misoprostol, and the clinical efficacy and adverse reactions in both groups were evaluated Comparative analysis. Results There was no significant difference in adverse reactions between the two groups (P> 0.05). The time of embryo excretion in the observation group was shorter than that in the control group, and the abortion rate was higher than that in the control group (P> 0.05). The difference was statistically significant (P <0.05). Conclusions Mifepristone 300 mg is more likely to be abused in the treatment of abortion during 8 to 10 weeks of gestation, and the abortion time of the embryo is significantly shortened, which will not increase the incidence of adverse reactions in patients and is worthy of clinical promotion .