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一、单克隆抗体的应用 1975年Kohler等以杂交瘤技术制备大量单克隆抗体(monoclonal antibody,MoAb),引起广泛重视。根据研究需要制备的各种MoAb已应用于血液学各个领域,并取得可喜进展。在白血病中的应用有以下方面。 1.用于鉴定细胞类型及分化程度 MoAb可用于鉴定造血细胞类型及亚型,比形态学、组织化学、功能检查和表面标志等方法更为可靠,主要用于淋巴细胞亚群的研究。
First, the application of monoclonal antibody In 1975, Kohler and other hybridoma technology to prepare a large number of monoclonal antibodies (monoclonal antibody, MoAb), aroused widespread attention. Various MoAb prepared according to the research needs have been applied to all fields of hematology, and made gratifying progress. The application of leukemia has the following aspects. 1. Used to identify cell type and degree of differentiation MoAb can be used to identify hematopoietic cell types and subtypes, more than morphological, histochemical, functional tests and surface markers and other methods more reliable, mainly for lymphocyte subsets.