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目的:研究宫颈癌放射治疗中患者腹部轮廓变化对患者受照剂量的影响。方法:选择15例接受调强放射治疗的宫颈癌患者。在Pinnacle V9.2治疗计划中把治疗前扫描得到的CBCT图像和计划CT图像进行融合配准。统计分析患者实际治疗时和首次放疗计划时的腹部体积变化,并在计划系统中模拟获得大体肿瘤区(GTV),临床肿瘤区(CTV),小肠、膀胱和直肠等危及器官在剂量学上的变化。结果:膀胱、小肠和直肠的40Gy剂量体积(V40)与外轮廓差值的相关系数分别为-0.75、-0.87、-0.79。CTV最小、平均、最大剂量与外轮廓差值的相关系数:-0.94、-0.95、-0.88。GTV的最小、平均、最大剂量的相关系数为0.71、-0.96、-0.91。结论:放射治疗过程中腹部体积变化对宫颈癌的剂量影响呈负相关。
Objective: To study the effect of abdominal contour changes on radiation dose in patients undergoing radiation therapy of cervical cancer. Methods: Fifteen patients with cervical cancer undergoing IMRT were selected. In the Pinnacle V9.2 treatment plan, the pre-treatment scan CBCT images and the planned CT images were fused and registered. The changes of abdominal volume at the time of the first treatment and the first radiotherapy were statistically analyzed. In the planning system, the gross tumor area (GTV), clinical tumor area (CTV), small intestine, bladder and rectum were measured in dose-dependent Variety. Results: The correlation coefficients between the 40 Gy dose volume (V40) and the contour of bladder, small intestine and rectum were -0.75, -0.87 and -0.79 respectively. Correlation coefficients of CTV minimal, average, maximum dose and outer contour difference: -0.94, -0.95, -0.88. GTV minimum, average, maximum dose correlation coefficient of 0.71, -0.96, -0.91. Conclusion: The change of abdominal volume during radiation therapy has a negative correlation with the dose of cervical cancer.