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目的：研究组织因子途径抑制物（Ｔｉｓｓｕｅ Ｆａｃｔｏｒ Ｐａｔｈｗａｙ Ｉｎｈｉｂｉｔｏｒ，ＴＦＰＩ）这一新型抗凝蛋白在脑出血与脑梗塞中的表达，探索其临床意义。方法：ＴＦＰＩ抗原（ＴＦＰＩ：Ａｇ）采用双夹心ＥＬＩＳＡ抗原测定法，ＴＦＰＩ活性（ＴＦＰＩ：Ａ）采用发色底物法。结果：脑出血（ ｎ＝１６）与脑梗塞（ ｎ＝４６）的 ＴＦＰＩ抗原与活性均高于对照组。有并发感染或并发糖尿病，高脂血症组高于无并发症组。结论：脑出血或脑梗塞患者出血管病变与血小板活化 ＴＦＰＩ增高，提示感染对血管内皮的持续损伤与某些炎症因子能刺激其释放。
Objective: To investigate the expression of Tissue Factor Pathway Inhibitor (TFPI), a new type of anticoagulant protein, in cerebral hemorrhage and cerebral infarction and to explore its clinical significance. Methods: TFPI antigen (TFPI: Ag) was assayed by double sandwich ELISA. TFPI activity (TFPI: A) was determined by chromogenic substrate method. Results: TFPI antigen and activity of cerebral hemorrhage (n = 16) and cerebral infarction (n = 46) were higher than that of control group. Have concurrent infection or complicated by diabetes, hyperlipidemia group was higher than non-complication group. Conclusion: The vascular lesions and platelet-activating TFPI in patients with cerebral hemorrhage or cerebral infarction are increased, suggesting that continuous infection of vascular endothelium and certain inflammatory factors can stimulate the release of TFPI.