药物过敏现象很常见,而医生有时不能及时发现,尤其是药物过敏引起的发热反应。现将我院内科病房1978年下半年所观察的药物热4例报告如下。【例1】傅××,女,18岁,因干咳、发热23天入院。体温38～39℃,体格检查无异常发现。血沉68毫米/小时。因患者与结核病人有密切接触史,故给予异烟肼和链霉素试治。住院初期仅下午发热,不伴寒战。用药1周后体温升至40～41℃,且上午、下午两次出现寒战和发热(链霉素0.5克,2次/日),颈部一淋巴结迅速增大,压痛明显,但剧烈干咳症状消失,一般情况良好。用抗结核治疗2周时体温更高,颈部淋巴结更肿大(病理检查示“反应性增生”),皮肤散在斑丘疹,血沉更快(94～102毫米/小时),考虑结核病可能性不大而停用上述两药。停药次日体温降至正常,肿大淋巴结很快消失,血沉逐步降至正常。停药3天后,因临床方面 Drug allergy is very common, and sometimes doctors can not be found in time, especially the hyperthermia caused by drug allergies. Now in our hospital medical ward in the second half of 1978 observed drug fever reported as follows. [Example 1] Fu × ×, female, 18 years old, due to dry cough, fever 23 days admitted. Body temperature 38 ~ 39 ℃, no abnormal physical examination found. ESR 68 mm / h. Patients and TB patients have close contact history, so give isoniazid and streptomycin test. Early hospital fever only in the afternoon, without chills. After 1 week of treatment, the body temperature rose to 40-41 ° C, chills and fever (streptomycin 0.5g, 2 times / day) appeared in the morning and afternoon twice. The neck lymph nodes rapidly increased and the tenderness was obvious. However, severe dry cough Disappear, generally good. With 2 weeks of treatment with anti-TB therapy, the temperature was higher, the neck lymph nodes were more enlarged (pathological examination showed “reactive hyperplasia”), the skin was scattered with rash and the erythrocyte sedimentation rate was faster (94-102 mm / h), considering the possibility of tuberculosis Large and discontinue the two drugs. The next day the body temperature dropped to normal, swollen lymph nodes disappear soon, ESR gradually reduced to normal. 3 days after stopping due to clinical aspects