刘铸晋等在测定钩吻素子(1)结构的工作中,发现它能被钠-醇还原裂解,亚胺基β位的醚键发生断裂,得到还原裂解产物-双氢钩吻醇(2)。其反应机理可能是一种自由基-阴离子反应,类似于苄基醚的还原断裂。 反应的关键一步是一个单电子在化合物(1)中的碳氮双键上的加成,生成一个自由基-阴离子,接着发生β-键断裂及质子化,这种过程连续进行三次以后,就得到还原 In the work of determining the structure of crookin (1), Liu et al. Found that it could be cleaved by sodium-alcohol and the ether bond at the β-position of imino group was cleaved, resulting in the reduction cleavage product, dicamba (2). The reaction mechanism may be a free radical - anion reaction, similar to the reduction of benzyl ether rupture. The key step of the reaction is the addition of a single electron to the double bond of carbon and nitrogen in compound (1) to form a radical-anion, followed by β-bond cleavage and protonation. This process is repeated three times Get restored