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氟乙酰胺中毒事件时有发生,近年来临床上对氟乙酰胺中毒十分重视,不断总结经验,并报道了其临床症状、临床诊断及治疗等有关知识,但是有关氟乙酰胺中毒的病理变化却报道的很少,而且采用人体组织的HE染色切片做回顾性调查研究的多,尚缺乏对氟乙酰胺中毒的法医毒理病理学的观察。笔者通过对8例氟乙酰胺中毒死亡案例的法医病理学检验观察分析,发现氟乙酰胺中毒的早期死亡与心功能衰竭有关,晚期死于肝肾功能衰竭;氟乙酰胺中毒肝、肾病变广泛且严重,肝细胞呈广泛性小泡性脂变可作为肝病危重标志;细胆管增生提示小叶外周带大量肝细胞坏死。
Fluoroacetamide poisoning has occurred from time to time in recent years, fluorodefenamide poisoning attaches great importance to the clinical experience, and reported its clinical symptoms, clinical diagnosis and treatment of other relevant knowledge, but the pathological changes of fluoroacetamide poisoning have been reported Few, and the use of HE tissue sections of human tissue to do a retrospective survey of more, there is no lack of forensic toxicology of fluoroacetamide poisoning pathological observation. The author of eight cases of death from fluoroacetamide poisoning forensic pathology test analysis and found that the early death of fluoroacetamide and heart failure related to heart failure, late death from liver and kidney failure; fluoroacetamide poisoning liver and kidney disease extensive And severe, hepatocytes showed extensive vesicular lipidosis as a marker of liver disease; bile duct hyperplasia prompted a large number of hepatocytes in the peripheral lobe necrosis.