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目的 探讨双水平气道正压无创通气 (BiPAP)对慢性阻塞性肺疾病 (COPD)合并Ⅱ型呼吸衰竭的治疗价值。方法 在 2 2例COPD合并Ⅱ型呼吸衰竭患者中随机选择 11例 ,进行规律性无创双水平气道正压机械通气辅助治疗 ,每日上机两次 ,每次 2h ,7天为一疗程 ,比较上机前 ,上机后 2h ,2 4h ,7天后动脉血气中PH值 ,PaO2 值 ,PaCO2 值及临床症状变化情况。结果 治疗组治疗后 2h ,2 4h ,7天动脉血气中PH值和PaO2 值逐渐上升 ,PaCO2 值下降 ,临床症状明显改善 ,有效率达 81.81% ,对照组动脉血气中PH值 ,PaO2 ,PaCO2 值及临床表现虽有不同程度的改善 ,但与治疗组同期比较 ,差异均有显著性 (P <0 .0 5 )。结论 无创双水平气道正压机械通气辅助治疗COPD合并Ⅱ型呼吸衰竭具有肯定的临床疗效
Objective To investigate the therapeutic value of bi-level positive airway pressure noninvasive ventilation (BiPAP) on type 2 respiratory failure and chronic obstructive pulmonary disease (COPD). Methods Twenty-two patients with COPD and type Ⅱ respiratory failure were randomly selected. Eleven patients underwent routine non-invasive bi-level positive airway pressure mechanical ventilation. Two times a day, each time being 2h and 7 days, The changes of PH value, PaO2 value, PaCO2 value and clinical symptoms in arterial blood gas were compared between 2h, 24h, Results The PH value and PaO2 value in arterial blood gas of 2h, 24h, 7d after treatment in treatment group gradually increased, PaCO2 value decreased, clinical symptoms improved obviously, the effective rate reached 81.81%. In the control group, PH value, PaO2, PaCO2 value And clinical manifestations, although with varying degrees of improvement, but compared with the treatment group over the same period, the difference was significant (P <0.05). Conclusions Noninvasive bi-level positive airway pressure mechanical ventilation has definite clinical effect in COPD with type Ⅱ respiratory failure