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目的探讨低分子肝素联合氯吡格雷治疗不稳定型心绞痛(UAP)的临床疗效。方法将96例UAP患者分为对照组48例和治疗组48例,二组均给予硝酸甘油注射液静滴,作为基础治疗,治疗组给予低分子肝素5 000U,每12h皮下注射,7d为一个疗程,氯吡格雷口服(停用阿司匹林),3周为1个疗程。于治疗前、中观察心绞痛发作的频率、发作间期、持续时间、24h缺血总时间、ST下移、心肌耗氧指数等以评价其疗效。结果二组患者治疗后,上述指标均有不同程度改善,治疗组较对照组改善更明显(P<0.05)。结论低分子肝素联合氯吡格雷治疗不稳定型心绞痛疗效肯定,不良反应少。
Objective To investigate the clinical efficacy of low molecular weight heparin combined with clopidogrel in the treatment of unstable angina pectoris (UAP). Methods Ninety-six UAP patients were divided into control group (n = 48) and treatment group (n = 48). Both groups were given intravenous nitroglycerin injection as the basic treatment. The treatment group was given low molecular weight heparin (5 000U), subcutaneous injection every 12 hours, Course of treatment, oral clopidogrel (discontinuation of aspirin), 3 weeks for a course of treatment. In the treatment before and after angina pectoris attack frequency, duration of attack, duration of 24h ischemic total time, ST down, myocardial oxygen consumption index to evaluate its efficacy. Results After treatment, the above indexes were improved to some extent in both groups, and the improvement in the treatment group was more obvious than that in the control group (P <0.05). Conclusion Low molecular weight heparin combined with clopidogrel is effective in treating unstable angina pectoris with few adverse reactions.