论文部分内容阅读
［目的］探索姑息放、化疗对鼻咽癌放疗后远处转移生存率的影响。［方法］１９８９年 １月一１９９２年 １２月 １２０例鼻咽癌 初次放疗后经胸片、Ｂ超、ＥＣＴ、ＣＴ及ＭＲＩ证实为远处转移者将患者分成２组。治疗组（６２例）采用姑息性放、化疗，化疗以ＣＦＰ、ＥＣＰ 等方案２－６周期，放疗采用局部姑息照射，骨转移Ｄ，Ｄｒ１５Ｇｙ－３０Ｇｙ、肺转移Ｄ_Ｔ５Ｇｙ－６０Ｇｙ、肝转移Ｄ_Ｔ３０Ｇｙ一５０Ｇｙ。非治疗组５８ 例。［结果］治疗组与非治疗组６个月、１２个月生存率比较：肝、肺转移Ｐ＜０．０１，骨转移Ｐ＜０．０５，多器官转移Ｐ＞０．０５，１８个月生 存率两组差异无显著性意义（Ｐ＞０．０５）［结论］姑息性放、化疗对远处单器官转移来说，提高６个月、１２个月生存率有显著意义， 尤其是肝和肺转移。１８个月各组差异统计学上无意义，说明要延长生存率需要寻求更好的治疗方法。
[Objective] To explore the effect of palliative and chemotherapy on the survival rate of distant metastasis of nasopharyngeal carcinoma after radiotherapy. [Methods] From January 1989 to December 1992, 120 patients with nasopharyngeal carcinoma who had distant metastasis after radiotherapy were divided into two groups by radiography, B ultrasound, ECT, CT and MRI. The patients in the treatment group (62 cases) were treated with palliative radiotherapy, chemotherapy and chemotherapy for 2-6 cycles with CFP and ECP. Radiotherapy was performed by local palliative irradiation, bone metastasis D, Dr15Gy-30Gy, lung metastasis D_T5Gy-60Gy, liver metastasis D_T30Gy-50Gy . 58 cases of non-treatment group. [Results] The survival rates of 6 months and 12 months in treatment group and non-treatment group were compared: liver and lung metastasis P <0.01, bone metastasis P <0.05, multiple organ metastasis P> 0.05 and 18 months There was no significant difference between the two groups in survival rate (P> 0.05). [Conclusion] Palliative radiotherapy and chemotherapy can improve the survival rate of 6 months and 12 months in distant single organ metastasis, especially liver And lung metastasis. The 18-month differences between the groups were statistically insignificant, indicating that to extend the survival rate need to seek better treatment.