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目的探讨妊娠期糖尿病(GDM)合并子前期(PE)对脐动脉血流及母婴妊娠结局的影响。方法选取2013年6月至2014年6月住院分娩的52例GDM合并PE孕妇(研究组)和同期52例正常健康孕妇(对照组)作为研究对象,应用彩色多普勒超声对两组孕妇产前1周内脐动脉血流情况进行检测,对两组孕妇脐动脉血流相关指标及妊娠结局进行比较。结果研究组孕妇脐动脉RI、PI及S/D值明显高于对照组(P<0.05);研究组孕妇剖宫产率(71.15%)明显高于对照组(36.54%)(P<0.05);研究组孕妇平均新生儿出生体质量及新生儿1 min Apgar评分明显低于对照组(P<0.05);研究组FGR、围生儿预后不良发生率也明显高于对照组(P<0.05)。结论妊娠糖尿病合并子前期可导致脐动脉血流动力学异常,增加不良妊娠结局发生的可能性,因此临床应进一步加强对此类孕产妇的综合监护。
Objective To investigate the effect of gestational diabetes mellitus (GDM) combined with preeclampsia (PE) on umbilical artery blood flow and maternal and infant pregnancy outcomes. Methods Totally 52 pregnant women with GDM (study group) and 52 healthy pregnant women (control group) who were hospitalized for delivery from June 2013 to June 2014 were enrolled in this study. Color Doppler echocardiography Umbilical artery blood flow in the first week before the test, the two groups of pregnant women umbilical artery blood flow-related indicators and pregnancy outcomes were compared. Results The RI, PI and S / D values of umbilical artery in study group were significantly higher than those in control group (P <0.05). The cesarean section rate in study group was significantly higher than that in control group (71.15% vs 36.54%, P <0.05) ; The average neonatal birth weight and the 1-minute Apgar score in the study group were significantly lower than those in the control group (P <0.05). In the study group, the incidence of adverse prognosis of FGR and neonates was also significantly higher than that of the control group (P <0.05) . Conclusion GDM may lead to abnormal hemodynamics of umbilical artery and increase the possibility of adverse pregnancy outcome. Therefore, the comprehensive supervision of such mothers should be further strengthened in clinic.