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目的 探讨突变型P53基因产物在胃癌中异常表达的意义。方法 应用免疫组织化学方法研究P53基因在98例胃痛中的表达。结果 98例胃癌标本中,P53表达阳性率为59.2％,与组织学类型无关,不同浸润深度胃癌与P53异常表达有关(P<0.05),肿瘤直径大于5cm者P53阳性率明显高于直径小于5cm者,在淋巴结转移组和无转移组间P53阳性程度有显著差异。结论 P53异常表达是胃癌重要标志之一。
Objective To investigate the significance of abnormal expression of mutant P53 gene in gastric cancer. Methods Immunohistochemistry was used to study the expression of P53 gene in 98 cases of stomach pain. Results The positive rate of P53 expression in 98 specimens of gastric cancer was 59.2%, which was not related to the histological type. Different depth of invasion of gastric carcinoma was associated with abnormal expression of P53 (P<0.05). The positive rate of P53 in tumors larger than 5cm was significantly higher than that of diameter less than 5cm. There was a significant difference in the degree of P53 positive between the lymph node metastasis group and the non-metastasis group. Conclusion The abnormal expression of P53 is one of the important markers of gastric cancer.