五氟利多(Penfluridol)是一种长效、口服、非镇静性抗精神病新药,主要用于各类急慢性精神分裂症的巩固维持治疗。该药属二苯丁呱啶的衍生物,其结构式为。为了探讨该药物对人体体细胞有无遗传毒理作用,以便为其临床长期使用提供更充分的实验依据,我们采用了多项细胞遗传学指标就五氟利多对正常人外周血培养细胞染色体的作用进行了系统观察,现将其对核仁形成区影响的观察结果报告如下。方法:五氟利多纯品(中南制药厂提供)加入三蒸 Penfluridol is a long-acting, oral, non-sedating antipsychotic drug mainly used for the consolidation and maintenance of various types of acute and chronic schizophrenia. The drug is a derivative of dibenzidine, its structural formula is. In order to investigate the genotoxicity of the drug on human somatic cells in order to provide a more adequate experimental basis for its clinical long-term use, we used a number of cytogenetic indicators on the perfusion of cell chromosomes The role of a systematic observation, now its impact on the formation of nucleolar areas were reported as follows. Method: Pentafluor and more pure products (provided by Central and South Pharmaceutical Factory) added three steam