本文概述当前百日咳综合征的流行病学、病理生理学、临床和预防等有关认识。流行病学美国自1951年最初应用百日咳菌苗以来,该病的发病率稳步下降。然而,现在美国许多地区的百日咳和百日咳综合征发病率有所回升。1983年头33周百日咳报告病例较1982年同期平均增高50%。在英国流行的百日咳,普遍认为是由于百日咳免疫人数的减少而致。如1967～1974年免疫率约为77%,而1978年仅为30%。成人也可发生百日咳,甚至包括有感染史或免疫史者。成人百日咳除出现突发性症 This article outlines the current epidemiology, pathophysiology, clinical and prevention of pertussis syndrome. Epidemiology The United States has had a steady decline in the incidence of the disease since the initial application of pertussis vaccine in 1951. However, the incidence of whooping cough and whooping cough syndrome has now rebounded in many parts of the United States. In the first 33 weeks of 1983, the reported cases of whooping cough increased by 50% on average over the same period of 1982. Pertussis, which is prevalent in the United Kingdom, is generally believed to have been due to a decrease in the number of people who have had pertussis immunization. For example, the immunization rate was about 77% from 1967 to 1974, up from 30% in 1978. Pertussis can occur in adults, including those with history of infection or immunization. Adult whooping cough in addition to the emergence of sudden illness