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目的比较不同体质量指数(BMI)的多囊卵巢综合征(PCOS)患者体外授精-胚胎移植(IVF-ET)的治疗结局。方法87例接受IVF-ET治疗的PCOS患者,根据BMI分4组:A组BMI<20 kg/m2,B组20~22.9 kg/m2,C组23~24.9 kg/m2,D组≥25 kg/m2。比较各组超排卵周期的基本资料、胚胎实验室数据及妊娠结局。结果D组促性腺激素用量与A组和B组相比均显著增加(P=0.01和P=0.037)。D组有效胚胎数与A、B、C三组相比均显著减少(分别为P=0.006,P=0.020和P=0.033)。各组临床妊娠率、流产率、活产率比较,差异均无统计学意义(P>0.05)。结论随着PCOS患者BMI的增大,促性腺激素用量增加;当BMI≥25 kg/m2时,有效胚胎数减少。
Objective To compare the outcomes of in vitro fertilization-embryo transfer (IVF-ET) in patients with polycystic ovary syndrome (PCOS) with different body mass index (BMI). Methods Eighty-seven PCOS patients undergoing IVF-ET were divided into 4 groups according to BMI: group A with BMI <20 kg / m2, group B with 20-22.9 kg / m2, group C with 23-24.9 kg / m2, group D with ≥25 kg / m2. The basic data of superovulation cycle, embryo laboratory data and pregnancy outcome were compared. Results The dosage of gonadotropin in group D was significantly higher than that in group A and group B (P = 0.01 and P = 0.037). The number of effective embryos in group D was significantly reduced compared with those in groups A, B and C (P = 0.006, P = 0.020 and P = 0.033, respectively). There was no significant difference in clinical pregnancy rate, abortion rate and live birth rate in each group (P> 0.05). Conclusions With the increase of BMI in patients with PCOS, the dosage of gonadotropin increased; when the BMI≥25 kg / m2, the number of effective embryos decreased.