临床前研究结果表明,一种安全的可作为预防应用的避孕药——WHI-07是一种新的叠氮胸苷(齐多夫定)芳香基磷酸盐衍生物。来自于美国明尼苏达圣保罗Parker Hughes研究所的Cruz教授指出,目前大量的兼有阴离子聚合体和去污剂双重功效的杀微生物剂被用于临床以抑制HIV-1的性传播途径。然而,该类药物的主要缺点是其与通过性途径传播的HIV-1株的亲和力较低,阻碍血凝过 Preclinical studies have shown that WHI-07 is a novel azidothymidine (zidovudine) arylphosphate derivative that is safe as a prophylactic contraceptive. Cruz, from the Parker Hughes Institute in St. Paul, Minnesota, USA, points out that currently a large number of microbicides that combine the dual benefits of anionic polymers and soil release agents are being used clinically to inhibit the sexual transmission of HIV-1. However, the major drawback of this class of drugs is their low affinity for the HIV-1 strain that is transmitted by the sexual route, impeding the clotting process