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目的:探讨灰区淋巴瘤(grey zone lymphoma,GZL)的临床和病理组织学特征。方法:应用光镜观察及免疫组化染色对2例GZL患者的病理标本进行分析,同时复习相关文献。结果:例1患者经右锁骨上淋巴结活检,其肿瘤病理组织学形态类似经典型霍奇金淋巴瘤(classic Hodgkin’s lymphoma,CHL),但肿瘤细胞免疫表型为CD30+、CD15-、CD20+。例2患者为纵隔肿瘤,肿块主要表现为弥漫性大B细胞淋巴瘤(diffuse large B cell lymphoma,DLB-CL),肿块边缘灶区分布霍奇金细胞和RS(Hodgkin’s and Reed-Sternberg,HRS)样细胞,这些细胞呈CD30+、CD15+、部分CD20+、CD79α+、BOB.1+、OCT2-,同时部分HRS样细胞呈EBV+。结论:本研究的2例GZL患者在组织学形态和免疫学表型上同时具有CHL和DLBCL的共同特点,预后较差。
Objective: To investigate the clinical and histopathological features of gray zone lymphoma (GZL). Methods: The pathological specimens of 2 GZL patients were analyzed by light microscopy and immunohistochemical staining, and the related literatures were reviewed. Results: In the case of the right supraclavicular lymph node biopsy, the histopathology of the patient was similar to that of classic Hodgkin’s lymphoma (CHL). However, the immunophenotypes of tumor cells were CD30 +, CD15- and CD20 +. Example 2 The patient was a mediastinal tumor. The mass mainly showed diffuse large B cell lymphoma (DLB-CL), Hodgkin’s and Reed-Sternberg (HRS) Like cells, these cells were CD30 +, CD15 +, some CD20 +, CD79a +, BOB.1 +, OCT2-, while some HRS-like cells were EBV +. Conclusion: The two GZL patients in our study have the common features of both CHL and DLBCL in histological morphology and immunological phenotype with poor prognosis.