论文部分内容阅读
microRNA(miRNA)是近年新发现并热点研究的一类大小约18～24nt的非编码单链小分子RNA,在转录后水平通过序列特异性翻译抑制或mRNA裂解来调控基因表达。多项研究显示,miR-NA参与恶性肿瘤的发生及肿瘤细胞的增殖、分化、凋亡、侵袭及转移等过程的调节。现将microRNA在宫颈癌的表达,特定miRNA在致癌过程中作用机制的研究进展作一综述,以冀为研究宫颈癌的发生发展提供新的思路。
MicroRNAs (miRNAs) are newly discovered and studied in recent years. A group of small non-coding RNAs about 18-24 nt in size are used to regulate gene expression at transcriptional level by sequence-specific translational inhibition or mRNA cleavage. A number of studies have shown that miR-NA is involved in the development of malignant tumors and the regulation of tumor cell proliferation, differentiation, apoptosis, invasion and metastasis. At present, the research progress of the expression of microRNAs in cervical cancer and the mechanism of action of specific miRNAs in carcinogenesis is reviewed, which will provide a new idea for the study of the occurrence and development of cervical cancer.