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观察含羟基喜树碱（ＨＣＰＴ）联合治疗方案治疗晚期胃肠道肿瘤６９例。其中ＨＣＰＴ并用５－氟脲嘧啶（５－ＦＵ）、叶酸治疗晚期大肠癌２９例。全部肠癌病人均接受了ＨＣＰＴ（１０～１２ｍｇ／天，静滴４小时，共１０天）治疗。其中１０例同时接受了低剂量５－ＦＵ（０．３５７ｇ／天，持续深静脉输注２１天）、叶酸片（第１天给予ＣＦ３００ｍｇ静滴，第２天起给予叶酸片２０ｍｇ／次，每天３次口服至２１天）治疗；另１９例接受了５－ＦＵ（０．７５ｇ／天，每天静滴４小时共５天）、ＣＦ（３０ｍｇ／天，静滴２小时，共５天）治疗。低剂量５－ＦＵ治疗组的有效率为５０％（５／１０），５例ＰＲ，３例ＮＣ，２例ＰＤ。５－ＦＵ治疗组的有效率为３６．８％（７／１９），７例ＰＲ，９例ＮＣ，３例ＰＤ。总有效率４１．３％。前者毒副作用以腹痛、腹泻为主，其中１例出现Ⅲ度腹痛腹泻。后者以局部静脉炎为主，发生率达９０．１％，白细胞下降率（４７．４％）高于前者（２０％）。ＨＣＰＴ单药或联合阿霉素（ＡＤＭ）、丝裂霉素（ＭＭＣ）治疗晚期胃癌４０例，单药治疗组５例，１例ＰＲ，有效率２０％；联合治疗组３５例，１２例ＰＲ，有效率３４．３％。毒副反应联合组高于单药组，以白细胞下降明?
Sixty-nine patients with advanced gastrointestinal cancer treated with combination therapy of HCPT were observed. HCPT and 5-fluorouracil (5-FU), folic acid in the treatment of advanced colorectal cancer in 29 cases. All patients with bowel cancer received HCPT (10-12 mg / day, intravenous infusion for 4 hours for 10 days). Among them, 10 patients received both low-dose 5-FU (0.357g / day, continuous deep vein infusion for 21 days), folic acid tablets (CF300mg on day 1 and folic acid tablets 20mg / 3 oral doses to 21 days); the other 19 patients received 5-FU (0.75 g / day iv for 4 hours for 5 days), CF (30 mg / day for 2 hours for 5 days) . The response rate was 50% (5/10) in low-dose 5-FU group, 5 in PR, 3 in NC, and 2 in PD. The 5-FU treatment group was 36.8% (7/19), PR was 7 cases, NC was 9 cases and PD was 3 cases. The total effective rate of 41.3%. The former side effects of abdominal pain, diarrhea, one case of Ⅲ degree abdominal pain and diarrhea. The latter with local phlebitis, the incidence of 90.1%, leukopenia (47.4%) higher than the former (20%). HCPT alone or in combination with doxorubicin (ADM) and mitomycin C (MMC) for advanced gastric cancer 40 cases, monotherapy group 5 cases, 1 case of PR, the effective rate of 20%; combination therapy group 35 cases, 12 cases of PR , Effective 34.3%. Toxicity in the combined group was higher than that in the single drug group, and leukocyte decreased obviously.