地诺单抗是一种特异性靶向核因子κB受体活化因子配体(RANKL)的单克隆抗体,其能抑制破骨细胞活化和发展,减少骨吸收,增加骨密度,用于绝经后妇女骨质疏松症的治疗,具有较好的安全性和有效性。现对本品药理作用、药动学、临床及安全性评价和药物相互作用等做一综述。 Denoxylate is a monoclonal antibody that specifically targets RANKL, a ligand that inhibits osteoclast activation and development, reduces bone resorption, increases bone mineral density and is used in postmenopausal women Treatment of osteoporosis in women, with good safety and effectiveness. Now the pharmacological effects of this product, pharmacokinetics, clinical and safety evaluation and drug interactions are reviewed.